Osmosis Jones_
"Every body needs a hero."
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Director
Peter Farrelly
Starring
Chris Rock, Laurence Fishburne, David Hyde Pierce
Box Office
$13.6M
Updated Feb 16, 2026
WHERE TO WATCH
Hoopla
FREE
2 countries
Tubi
FREE
1 country
The Roku Channel
FREE
1 country
Plex
FREE
1 country
DROPTHE_ GOSSIP
Box office
Osmosis Jones earned $13.6M against a $75.0M budget.
Peter Farrelly →
Year context
Osmosis Jones was released 25 years ago in 2001.
CAST (20)
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
KA
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
MC
Michael Carven
Additional Character Voices (voice)
PC
Paul Christie
Dan Matter / Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
CREW
Director
Writer
BOX OFFICE
$75.0M
Budget
$13.6M
Revenue
-82%
ROI
FLOP
Verdict
STUDIOS (3)
DETAILS
Release
Status
Released
Runtime
95 min (1h 35m)
Language
English
Country
Rating
6.5/10 (1,064 votes)
Popularity
5
Budget
$75,000,000
Box Office
$13,596,911
Profit
$-61,403,089
IMDB
Trailer
FREQUENTLY ASKED QUESTIONS
What is Osmosis Jones about?
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
How long is Osmosis Jones?
Osmosis Jones has a runtime of 95 minutes (1h 35m).
Who directed Osmosis Jones?
Osmosis Jones was directed by Peter Farrelly.
Who stars in Osmosis Jones?
The cast of Osmosis Jones includes Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood, Elena Franklin.
How much did Osmosis Jones make at the box office?
Osmosis Jones earned $13,596,911 worldwide at the box office. The production budget was $75,000,000.
What is the rating of Osmosis Jones?
Osmosis Jones has a rating of 6.5 out of 10 based on 1,064 votes on TMDB.
GENRES (6)
Adventure
Animation
Action
Comedy
Family
Science Fiction
KEYWORDS (4)
cold
flu
lethal virus
construction worker