Side Effects_
"Love is a drug!"
America! Built on a better pill. Karly Hert has spent the last ten years selling drugs. Legally, that is. Karly is a pharmaceutical sales representative. She sells pills to doctors. She makes lots of money. She has a company car. She has a nice fat expense account. But there's a growing pit in Karly's stomach. Something isn't right behind the scenes at big pharma. Based on the director's decade working directly for the industry.
Starring
Katherine Heigl, Lucian McAfee, David Durbin
Box Office
$3K
Updated Feb 16, 2026
WHERE TO WATCH
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Year context
Side Effects was released 21 years ago in 2005.
Overview
America! Built on a better pill. Karly Hert has spent the last ten years selling drugs. Legally, that is. Karly is a pharmaceutical sales representative. She...
Side Effects is a Comedy, Drama, Romance film with a runtime of 1h 30m.
CAST (20)
Katherine Heigl
Karly Hert
LM
Lucian McAfee
Zach Danner
DD
David Durbin
Dan
DD
Dorian DeMichele
Jacqueline
TH
Temeceka Harris
Grace
BH
Beth Hebert
Sarah
Mimi Sagadin
Katie
SA
Sandy Adell
Dr. Jones
DM
David M. Ames
Dr. Jakobs
JA
John Apple
Plant Manager
RB
Ron Baumgartner
Business Man @ Plant
CS
Collin Spencer
T. Bates
BB
Bill Bolz
Scary Man
SB
Stacy Brickson
Dr. Collins
NC
Nathan Caracter
Recruiter
TC
Tom Christianson
Dr. Michaels
NC
Nathan Connor
Scott
JC
Janet Cresson
Debbie
TC
Tom Curtis
Dr. Allen
LE
Lee Ernst
Jack Klug
BOX OFFICE
$3K
Revenue
DETAILS
Release
Status
Released
Runtime
90 min (1h 30m)
Country
Rating
5.6/10 (40 votes)
Box Office
$2,523
FREQUENTLY ASKED QUESTIONS
What is Side Effects about?
America! Built on a better pill. Karly Hert has spent the last ten years selling drugs. Legally, that is. Karly is a pharmaceutical sales representative. She sells pills to doctors. She makes lots of money. She has a company car. She has a nice fat expense account. But there's a growing pit in Karly's stomach. Something isn't right behind the scenes at big pharma. Based on the director's decade working directly for the industry.
How long is Side Effects?
Side Effects has a runtime of 90 minutes (1h 30m).
Who stars in Side Effects?
The cast of Side Effects includes Katherine Heigl, Lucian McAfee, David Durbin, Dorian DeMichele, Temeceka Harris.
How much did Side Effects make at the box office?
Side Effects earned $2,523 worldwide at the box office.
What is the rating of Side Effects?
Side Effects has a rating of 5.6 out of 10 based on 40 votes on TMDB.
GENRES (3)
Comedy
Drama
Romance